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AssigneeUniversity of Southern California
InventorsFrederick L. Hall, Erlinda M. Gordon, Vaughn A. Starnes, W. French Anderson
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The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
A fusion polypeptide comprising a collagen binding domain and an angiogenesis modulating agent.
A nucleic acid sequence encoding a fusion polypeptide comprising a collagen binding domain and an angiogenesis modulating agent.
A method for locally altering circulation in a subject, comprising:
A method for locally altering circulation in a subject, comprising:
A tissue graft, comprising isolated tissue comprising endothelial cells treated with a fusion polypeptide comprising a collagen binding domain linked to an angiogenesis modulating agent.
A method of preparing a tissue graft comprising contacting isolated tissue with an effective amount of a fusion polypeptide comprising a collagen binding domain linked to an angiogenesis modulating agent.
A method of activating a graft comprising:
A pharmaceutical composition comprising a fusion polypeptide comprising a collagen binding domain linked to an angiogenesis modulating agent in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a nucleic acid encoding a fusion polypeptide comprising a collagen binding domain linked to an angiogenesis modulating agent in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.