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OwnerMasafumi Tsujimoto, Fuyuki Iwasa +7inventors
InventorsMasafumi Tsujimoto, Fuyuki Iwasa, Nobuo Tsuruoka, Hiroshi Nakazato, Kenju Miura, Nobuhiro Ishida, Tatsuya Kurihara, Kozo Yamaichi, Nozomi Yamaguchi
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A novel megakaryocyte differentiation factor, for example, consisting essentially of SEQ ID NO: 30; DNA coding for the megakaryocyte differentiation factor, an expression vector comprising the DNA, a host transformed with the expression vector, and a process for production of the megakaryocyte differentiation factor using the host. The megakaryocyte differentiation factor accelerates differentiation of megakaryocytes in the presence of IL-3, and acts as a thrombopoietin, and therefore an effective medicament to various diseases involving a decrease in platelete.
A megakaryocyte differentiation factor having the following properties;
A megakaryocyte differentiation factor essentially consisting of the amino acid sequence shown in SEQ ID NO:
A megakaryocyte differentiation factor having an amino acid sequence wherein one or more than one amino acid residue in the amino acid sequence shown in SEQ ID NO:
A megakaryocyte differentiation factor obtainable from a culture of transformed cells constructed by a gene recombination technique using a polynucleotide hybridizable with a polynucleotide coding for at least one of the amino acid sequences shown in SEQ ID NO:
Dependencies are inferred from the claim text.