Methods and compositions for treating and preventing infection using human interferon regulatory factor 3
AssigneeHuman Genome Sciences, Inc.
InventorsPaul A. Moore, Paula Pith-Rowe
Life of this patent
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Abstract
The present invention relates to IRF3 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human IRF3 protein. IRF3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods of gene therapy using polynucleotides encoding IRF3 polypeptides, fragments or variants to treat, prevent or ameliorate infectious diseases.
Claims36
An isolated polynucleotide comprising a nucleic acid sequence selected from the group consisting of:
- (a) a polynucleotide encoding amino acids 1-427 of SEQ ID NO:2
- (b) a polynucleotide encoding amino acids 1-407 of SEQ ID NO:2;
- (c) a polynucleotide encoding amino acids 2-427 of SEQ ID NO:2;
- (d) a polynucleotide encoding amino acids 198-381 of SEQ ID NO:2;
- (e) a polynucleotide encoding amino acids 382-407 of SEQ ID NO:2;
- (f) a polynucleotide encoding amino acids 408-427 of SEQ ID NO:2;
- (g) a polynucleotide encoding amino acids 306-427 of SEQ ID NO:2;
- (h) a polynucleotide encoding the amino acid sequence encoded by the cDNA contained in ATCC Deposit No. 97242;
- (i) a polynucleotide encoding at least 30 contiguous amino acids of SEQ ID NO:2 or the cDNA clone contained in ATCC Deposit No. 97242;
- (j) a polynucleotide encoding at least 50 contiguous amino acids of SEQ ID NO:2 or the CDNA clone contained in ATCC Deposit No. 97242;
- (k) a polynucleotide of at least 30 contiguous nucleotides of SEQ ID NO:
- 1 or the coding strand of the cDNA clone contained in ATCC Deposit No. 97242;
- (l) a polynucleotide of at least 40 contiguous nucleotides of SEQ ID NO:
- 1 or the coding strand of the cDNA clone contained in ATCC Deposit No. 97242;
- (m) a polynucleotide of at least 50 contiguous nucleotides of SEQ ID NO:
- 1 or the coding strand of the cDNA clone contained in ATCC Deposit No. 97242;
- (n) a polynucleotide of at least 60 contiguous nucleotides of SEQ ID NO:
- 1 or the coding strand of the cDNA clone contained in ATCC Deposit No. 97242;
- and
- (o) the complement of (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), or (m).
An isolated polynucleotide that hybridizes to SEQ ID NO:1 or the cDNA clone contained in ATCC Deposit No. 97272, wherein said hybridization takes place under stringent hybridization conditions.
Dependencies are inferred from the claim text.