Receptor based antagonists and methods of making and using
OwnerNeil Stahlinventor
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Abstract
The present invention provides a fusion polypeptide that forms a multimer that is capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.
Claims20
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 38A-38H encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 38A-38H, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 39A-39G encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 39A-39G, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 40A-40I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 40A-40I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 41A-41H encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 41A-41H, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 42A-42I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 42A-42I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 43A-43G encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 43A-43G, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 44A-44I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 44A-44J, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 45A-45I encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 45A-45I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 46A-461 encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 46A-46I, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
An isolated nucleic acid molecule having the nucleotide sequence set forth in FIGS. 47A-47J encoding a fusion polypeptide having the amino acid sequence set forth in FIGS. 47A-47J, wherein the fusion polypeptide forms a multimer that is capable of binding a cytokine to form a nonfunctional complex.
Dependencies are inferred from the claim text.