Isolated nucleic acid molecules encoding ESO-1 peptides and uses thereof
AssigneeLudwig Institute for Cancer Research
InventorsElisabeth Stockert, Elke Jager, Yao-Tseng Chen, Matthew Scanlan, Knuth Alexander, Lloyd J. Old
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Abstract
The invention relates to antibodies which bind to the cancer associated antigen NY-ESO-1. Both polyclonal and monoclonal antibodies are part of the invention, as are chimeric forms of the antibodies, and binding portions of antibodies. Uses of these antibodies are described. Also described are truncated, recombinant forms of the cancer associated antigen.
Claims21
An isolated antibody or binding fragment of an antibody which binds with a protein which is encoded by an isolated nucleic acid molecule, the complementary sequence of which hybridizes, under stringent conditions, to a nucleic acid molecule comprising nucleotides 54-593 of SEQ ID NO:
- 1.
A method for determining presence of antibodies against a cancer associated antigen in a sample, comprising contacting said sample with an isolated protein encoded by a nucleic acid molecule which comprises nucleotide 54-593 of SEQ ID NO:
- 1, and determining binding of antibodies thereto as a determination of antibodies against a cancer associated antigen in said sample.
A method for determining regression, progression of onset of a cancerous condition comprising monitoring a sample from a patient with said cancerous condition for a parameter selected from the group consisting of (i) NY-ESO-1 protein, and (ii) a peptide derived from NY-ESO-1 protein, with an antibody which binds to (i) or (ii), wherein amount of said parameter is indicative of progression or regression or onset of said cancerous condition.
A method for treating a subject afflicted with a cancerous condition comprising administering to said subject an antibody which specifically binds to NY-ESO-1 protein or to an ESO-1 derived peptide expressed on a cancerous cell associated with said cancerous condition, said antibody being coupled to an anticancer agent, in an amount sufficient to treat said cancerous condition.
A method for treating a subject afflicted with a cancerous condition comprising administering to said subject an antibody which specifically binds to NY-ESO-1, said antibody being coupled to an anticancer agent, in an amount sufficient to treat said cancerous condition.
Isolated protein consisting of at least amino acids 10-121 and no more than amino acids 10-180 of the protein encoded by the isolated nucleic acid molecule having the nucleotide sequence set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.