Protein-protein interactions in neurodegenerative diseases
AssigneeMyriad Genetics, Inc.
InventorsJean-Marc Roch, Paul L. Bartel, Karen Heichman
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Abstract
The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
Claims73
An isolated protein complex comprising two proteins, the protein complex selected from the group consisting of:
- (a) a complex of Fe65 and PN7740;
- (b) a complex of a fragment of Fe65 and PN7740;
- (c) a complex Fe65 and a fragment of PN7740;
- (d) a complex of a fragment of Fe65 and a fragment of PN7740;
- (e) a complex of PSD95 and PN7740;
- (f) a complex of a fragment of PSD95 and PN7740;
- (g) a complex PSD95 and a fragment of PN7740;
- and
- (h) a complex of a fragment of PSD95 and a fragment of PN7740;
A composition comprising:
- a first expression vector having a nucleic acid encoding a ligand or a homologue or derivative or fragment thereof, said ligand selected from the group consisting of Fe65 and PSD95;
- and
- a second expression vector having a nucleic acid encoding PN7740, or a homologue or derivative or fragment thereof.
A host cell comprising:
- a first expression vector having a nucleic acid encoding a first protein which is ligand or a homologue or derivative or fragment thereof, wherein said ligand is selected from the group consisting of Fe65 and PSD95;
- and
- a second expression vector having a nucleic acid encoding a second protein which is PN7740, or a homologue or derivative or fragment thereof.
An isolated protein complex having a first protein which is Fe65 or a homologue or derivative or fragment thereof interacting with a second protein which is PN7740 or a homologue or derivative or fragment thereof.
A fusion protein having a first polypeptide covalently linked to a second polypeptide, wherein said first polypeptide is Fe65 or a homologue or derivative or fragment thereof, and wherein said second polypeptide is PN7740 or a homologue or derivative or fragment thereof.
An isolated protein complex having a first protein which is PSD95 or a homologue or derivative or fragment thereof interacting with a second protein which is PN7740 or a homologue or derivative or fragment thereof.
A fusion protein having a first polypeptide covalently linked to a second polypeptide, wherein said first polypeptide is PSD95 or a homologue or derivative or fragment thereof, and wherein said second polypeptide is PN7740 or a homologue or derivative or fragment thereof.
Dependencies are inferred from the claim text.