Methods and compositions for delivery and retention of active agents to lymph nodes
AssigneeBoard of Regents, The University of Texas System
InventorsBeth A. Goins, William T. Phillips
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Abstract
The present invention is directed to delivery and retention of active agents to targeted lymph nodes in a mammal using a ligand/anti-ligand pair. More particularly, the invention involves methods, compositions, and kits for delivery and retention of active agents to targeted lymph nodes using compositions comprising a ligand-colloid moiety and compositions comprising an anti-ligand. Active agents may be associated with one or more of the colloid, ligand, or anti-ligand. Conjugation of the ligand and anti-ligand after administration permits retention of aggregated colloid complex in targeted lymph nodes.
Claims28
A method for delivery and retention of an active agent in one or more targeted lymph nodes, comprising:
- a) injecting into a mammal a first composition comprising ligand conjugated to a colloid;
- and
- a) injecting into said mammal a second composition comprising anti-ligand, wherein said anti-ligand binds to said ligand.
A method for detecting one or more sentinel lymph nodes comprising:
- a) injecting in the vicinity of a tumor in a mammal a first composition comprising ligand conjugated to a colloid;
- and
- b) injecting into said mammal a second composition comprising anti-ligand, wherein said anti-ligand binds to said ligand.
A kit for delivering and retaining an active agent in one or more lymph nodes, comprising:
- a) a first composition comprising ligand conjugated to a colloid;
- and
- b) a second composition comprising anti-ligand.
A composition comprising:
- a) ligand conjugated to colloid, and
- b) anti-ligand.
Dependencies are inferred from the claim text.