Testing endosymbiont cellular organelles and compounds identifiable therewith
AssigneePrimaGen Holding B.V.
InventorsBob van Gemen, Eveline Catherina A. C. Timmermans, Anthonij de Ronde, Irene Johanna M. Dobbelaer
Life of this patent
Estimating the term…
Abstract
The invention relates to the diagnosis of disease or the determination of functioning of cellular organisms, being of multi-cellular or unicellular nature, being visible by the naked eye or being a microorganism. The invention provides a method for determining functioning of a cellular organism comprising determining the relative ratio of a first endosymbiont cellular organelle nucleic acid and/or gene product thereof in a sample obtained from said organism in relation to the amount of a second nucleic acid and/or gene product thereof.
Claims40
A method of determining whether or not a cellular organism is functioning properly, said method comprising:
- obtaining a sample from said cellular organism;
- and
- determining a relative ratio of a first nucleic acid and/or gene product thereof of a first endosymbiont cellular organelle in said sample and a second nucleic acid and/or gene product thereof of said cellular organism.
A method of determining the staging of a disease, said method comprising:
- obtaining a sample from an organism suffering from or at risk of suffering from said disease;
- and
- determining a relative ratio of a nucleic acid and/or gene product thereof of an endosymbiont cellular organelle and a second nucleic acid and/or gene product thereof in said sample.
A method of determining therapeutic activity, toxic activity and/or possible side-effects of a candidate compound for treatment of malfunctioning of a cellular organism, comprising:
- introducing a candidate compound to a cellular organism;
- obtaining a sample from said cellular organism;
- and
- determining a relative ratio of first nucleic acid and/or gene product thereof of an endosymbiont cellular organelle and a second nucleic acid and/or gene product thereof in said sample.
A method of determining therapeutic activity and/or possible side-effects of a medicament, said method comprising:
- introducing a medicament to an organism;
- and
- determining a relative ratio of first nucleic acid and/or gene product thereof of an endosymbiont cellular organelle and a second nucleic acid and/or gene product thereof in a sample obtained from said organism.
The method according to any one of claims 16 to 21, wherein said therapeutic activity comprises a therapeutic activity against an HIV-related disease and/or a tumor-related disease.
Dependencies are inferred from the claim text.