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OwnerSean Chapman, William O. Dawson +6inventors
InventorsSean Chapman, William O. Dawson, Jonathan Donson, Monto H. Kumagai, Dennis J. Lewandowski, John A. Lindbo, Gregory P. Pogue, Shailaja Shivprasad
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The present invention provides a method for enhancing the production of RNAs or proteins in a plant host using either non-native 5′ untranslated sequences or artificial leader sequences. Preferably, commercially useful proteins, polypeptides, or fusion products thereof are produced, such as, enzymes, antibodies, hormones, pharmaceuticals, vaccines, pigments, anti-microbial polypeptides, and the like. The non-native 5′ untranslated enhancers may also be effective in many different types of transcription or translation systems, such as bacterial and animal systems.
A recombinant viral nucleic acid comprising:
A recombinant viral nucleic acid comprising a non-native sequence inserted in any nucleotide position 5′ to the initiation codon of said recombinant viral nucleic acid, wherein the amount of RNA or protein produced from said recombinant viral nucleic acid is increased compared to the amount produced in the absence of said non-native sequence, wherein said recombinant viral nucleic acid comprises less than an infective viral genome, wherein said non-native sequence comprises an untranslated leader sequence.
A method for enhancing the production of a protein in a host comprising the steps of expressing in said host a recombinant viral nucleic acid comprising:
A method for enhancing the production of a protein in a host comprising the steps of expressing in said host a recombinant viral nucleic acid comprising:
Dependencies are inferred from the claim text.