Characterization of an antibiotic impregnated delivery system as an intracanal medicament in endodontic therapy
AssigneeForsyth Dental Infirmary for Children
InventorsMario Abdennour, Philip Stashenko, Michele Scrime, Jack Gilad, Max Goodson
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Abstract
Endodontic fibers comprising a biocompatible polymer vehicle permeable to medicaments, or combinations of medicaments are described. Such fibers can be used, for example, in a method for the local delivery and sustained release of medicaments to periodontal or intracanal treatment sites. Endodontic fibers described include modified periodontal fibers and intracanal fibers.
Claims20
An endodontic fiber suitable for the local delivery and sustained release of one or more medicaments incorporated therein to an intracanal treatment site, comprising a copolymer vehicle having incorporated therein one or more medicaments.
A modified periodontal fiber suitable for the delivery and sustained release of medicament incorporated therein to an intracanal treatment site, comprising a copolymer vehicle having incorporated therein one or more medicaments, wherein the copolymer is treated to decrease its surface tackiness and increase its rigidity.
A method for the local delivery and sustained release of a medicament to an intracanal treatment site comprising:
- (a) obtaining an endodontic fiber suitable for intracanal use having one or more medicaments incorporated therein;
- (b) positioning the fiber of (a) in the root canal such that the fiber is in direct contact with the treatment site;
- and
- (c) maintaining the fiber at the treatment site,
- wherein the medicament is delivered to the treatment site at a controlled rate.
A method of treating an endodontic bacterial infection comprising the steps of:
- (a) obtaining an endodontic fiber suitable for intracanal use having one or more medicaments incorporated therein;
- (b) inserting the fiber of (a) into the root canal such that the fiber is in direct contact with the treatment site;
- and
- (c) maintaining the fiber at the treatment site,
- wherein the antibiotic is delivered to the treatment site.
A method of disinfecting a root canal receiving endodontic treatment comprising:
- (a) obtaining an endodontic fiber suitable for intracanal use having one or more medicaments incorporated therein;
- (b) inserting the fiber of (a) into a debrided and irrigated root canal such that the fiber is in direct contact with the treatment site;
- and
- (c) maintaining the fiber at the treatment site,
- wherein the medicament is administered to the treatment site at a controlled rate.
A method of reducing inflamation in periapical tissue of a tooth undergoing endodontic treatment, comprising:
- (a) obtaining an endodontic fiber suitable for intracanal use having incorporated therein an anti-inflammatory agent;
- (b) positioning the fiber into a debrided and irrigated root canal such that the fiber is in direct contact with the inflamed tissue;
- and
- (c) maintaining the endodontic fiber at the treatment site,
- wherein the anti-inflammatory agent is delivered to the site of inflammation.
An intracanal fiber which is an ethylene vinyl acetate copolymer comprising less than about 20% vinyl acetate.
Dependencies are inferred from the claim text.