Polymeric systems for drug delivery and uses thereof
OwnerJohn Jackson, Xichen Zhang +1inventors
InventorsJOHN JACKSON, XICHEN ZHANG, HELEN BURT
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Abstract
Biodegradable polymeric implants can provide a safe and efficient means to deliver drugs in the treatment of various diseases. Although a polymeric drug delivery system can be implanted as a solid device within a subject, it is also possible to administer such a system as an injectable liquid which solidifies in vivo. An improved formulation of a polymeric drug delivery system comprises a water insoluble copolymer that is a solid or wax at 37° C., a water soluble polymer that is a liquid at 25° C., and a hydrophobic drug. These drug delivery systems can be administered by injection, and do not require the use of a toxic curing agent or inconvenient temperature manipulations.
Claims62
A polymeric drug delivery system, comprising:
- (a) a biodegradable water insoluble polymer that is a solid or wax at 37° C.;
- (b) a biodegradable water soluble polymer that is a liquid at 25° C.;
- and
- (c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25° C.
A method for delivering a drug to a subject, comprising the administration of a polymeric drug delivery system that comprises (a) a biodegradable water insoluble polymer that is a solid or wax at 37° C., (b) a biodegradable water soluble polymer that is a liquid at 25° C., and (c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25° C.
A method of preparing a polymeric drug delivery system, comprising the blending of:
- (a) a biodegradable water insoluble polymer that is a solid or wax at 37° C., (b) a biodegradable water soluble polymer that is a liquid at 25° C., and (c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25° C.
A triblock copolymer of the formula ABA, wherein A is a block of residues comprising residues which remain after polymerization of one or more monomers selected from the group consisting of hydroxyacetic acid, 2-hydroxypropionic acid and 6-hydroxyhexanoic acid, B is a block of residues comprising residues which remain after the polymerization of one or more monomers selected from the group consisting of alkylene oxide and alkylene glycol, and the copolymer has a consistency, at a temperature within the range of 25-40° C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25° C.
A drug delivery system comprising a drug in combination with a triblock copolymer of the formula ABA, wherein A is a block of residues comprising residues which remain after polymerization of one or more monomers selected from the group consisting of hydroxyacetic acid, 2-hydroxypropionic acid and 6-hydroxyhexanoic acid, B is a block of residues comprising residues which remain after the polymerization of one or more monomers selected from the group consisting of alkylene oxide and alkylene glycol, and the copolymer has a consistency, at a temperature within the range of 25-40° C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25° C.
A method of administering a drug to a subject comprising contacting the subject with a drug delivery system comprising a drug in combination with a triblock copolymer of the formula ABA, wherein A is a block of residues comprising residues which remain after polymerization of one or more monomers selected from the group consisting of hydroxyacetic acid, 2-hydroxypropionic acid and 6-hydroxyhexanoic acid, B is a block of residues comprising residues which remain after the polymerization of one or more monomers selected from the group consisting of alkylene oxide and alkylene glycol, and the copolymer has a consistency, at a temperature within the range of 25-40° C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25° C.
Dependencies are inferred from the claim text.