Use of polyamino acid derivatives to treat seborrhoea and the associated skin disorders

A process according to claim 1, wherein in said polyamino acid derivatives of formula (I) and salts thereof, at least one of the following definitions apply:

• X is chosen from O, S, NH and NR″, wherein R″ is chosen from saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• R1 is chosen from linear and branched, saturated and unsaturated C8-40 hydrocarbon-based radicals,
• R2 is hydrogen;
• R3 is chosen from saturated, linear and branched C1-6 hydrocarbon-based radicals;
• and
• n is chosen from a number ranging from 2 to 100 and a number chosen such that the number average molecular weight of said polyamino acid derivative ranges from 150 to 10,000.

A process according to claim 1, wherein in said polyamino acid derivatives of formula (I) and salts thereof, at least one of the following definitions apply:

• X is chosen from O, S and NH;
• R1 is chosen from linear and branched, saturated C10-24 hydrocarbon-based radicals;
• and linear and branched unsaturated hydrocarbon-based radicals;
• R2 is hydrogen;
• R3 is a methyl radical;
• and
• n is chosen from a number ranging from 4 to 50 and a number chosen such that the number average molecular weight of said polyamino acid derivative ranges from 300 to 8,000.

A process according to claim 1, wherein:

• X is chosen from O, S and NH;
• R1 is chosen from linear and branched, saturated C10-24 hydrocarbon-based radicals;
• and linear and branched unsaturated hydrocarbon-based radicals;
• R2 is hydrogen;
• R3 is a methyl radical;
• and
• n is chosen from a number ranging from 4 to 50 and a number chosen such that the number average molecular weight of said polyamino acid derivative ranges from 300 to 8,000.

A process for the manufacture of a composition for treatment of at least one condition chosen from seborrhoea of the skin and scalp, disorders associated with seborrhoea, and disorders associated with microorganisms of the genus Propionibacterium, said process comprising:

• including in said composition at least one polyamino acid derivative chosen from formula (I) and salts thereof,
• 9
• in which:
• X is chosen from O, S, NH and NR″ with R″ is chosen from saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• R1 is chosen from:
• (i) hydrogen;
• (ii) linear and branched, saturated and unsaturated C1-6 hydrocarbon-based radicals,
• (iii) radicals of the formula
• 10
• wherein s is a number chosen from 0, 1, 2, 3 and 4;
• and R4 is chosen from hydrogen and radicals chosen from —NH2, —OH, —SH, —CHOHCH3, —CONH2, —NH—C(NH2)═NH, —C6H5, —C6H4OH and
• 11
• and;
• (iv) radicals of the formula
• 12
• wherein m is a number chosen from 3, 4 and 5;
• R2 is chosen from hydrogen;
• saturated and unsaturated, linear and branched C1-8 hydrocarbon-based radicals;
• and radicals chosen from —CH2C6H5, —CH2C6H4OH, —CH2OH, —CHOHCH3, —(CH2)t—NH2 wherein t is a number chosen from 3, 4 and 5;
• R3 is chosen from hydrogen and saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• and
• n is a number greater than 1 chosen such that the number average molecular weight of the polyamino acid derivative ranges from 100 to 200 000;
• wherein the repeating unit may be identical or different for the same derivative.

An anti-seborrhoeic composition comprising,

• a physiologically acceptable medium;
• and
• an effective amount of at least one polyamino acid derivative of formula (I) and salts thereof,
• 13
• in which:
• X is chosen from O, S, NH and NR″ wherein R″ is chosen from saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• R1 is chosen from:
• (i) hydrogen;
• (ii) linear and branched, saturated and unsaturated C1-40 hydrocarbon-based radicals,
• (iii) radicals of the formula
• 14
• wherein s is a number chosen from 0, 1, 2, 3 and 4;
• and R4 is chosen from hydrogen and radicals chosen from —NH2, —OH, —SH, —CHOHCH3, —CONH2, —NH—C(NH2)═NH, —C6H5, —C6H4OH and
• 15
• and;
• (iv) radicals of the formula
• 16
• wherein m is a number chosen from 3, 4 and 5;
• R2 is chosen from hydrogen;
• saturated and unsaturated, linear and branched C1-8 hydrocarbon-based radicals;
• and radicals chosen from —CH2C6H5, —CH2C6H4OH, —CH2OH, —CHOHCH3, —(CH2)t—NH2 wherein t is a number chosen from 3, 4 and 5;
• R3 is chosen from hydrogen and saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• and
• n is a number greater than 1 chosen such that the number average molecular weight of the polyamino acid derivative ranges from 100 to 200 000;
• wherein the repeating unit may be identical or different for the same derivative.

An anti-bacterial composition comprising,

• a physiologically acceptable medium;
• and
• an effective amount of at least one polyamino acid derivative of formula (I) and salts thereof for treating bacteria,
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• in which:
• X is chosen from O, S, NH and NR″ wherein R″ is chosen from saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• R1 is chosen from:
• (i) hydrogen;
• (ii) linear and branched, saturated and unsaturated C1-40 hydrocarbon-based radicals,
• (iii) radicals of the formula
• 18
• wherein s is a number chosen from 0, 1, 2, 3 and 4;
• and R4 is chosen from hydrogen and radicals chosen from —NH2, —OH, —SH, —CHOHCH3, —CONH2, —NH—C(NH2)═NH, —C6H5, —C6H4OH and
• 19
• and;
• (iv) radicals of the formula
• 20
• wherein m is a number chosen from 3, 4 and 5;
• R2 is chosen from hydrogen;
• saturated and unsaturated, linear and branched C0-8 hydrocarbon-based radicals;
• and radicals chosen from —CH2C6H5, —CH2C6H4OH, —CH2OH, —CHOHCH3, —(CH2)t—NH2 wherein t is a number chosen from 3, 4 and 5;
• R3 is chosen from hydrogen and saturated and unsaturated, linear and branched C1-6 hydrocarbon-based radicals;
• and
• n is a number greater than 1 chosen such that the number average molecular weight of the polyamino acid derivative ranges from 100 to 200 000;
• wherein the repeating unit may be identical or different for the same derivative.