Inhibitors of viral infection
OwnerKarla Kirkegaard, Kathy Richmond +3inventors
InventorsKarla Kirkegaard, Kathy Richmond, John Lyle, Steve Schultz, Scott Hobson
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Abstract
The present invention provides a viral RNA-dependent RNA polymerase pharmacophore which is characterized by binding to a conserved interface binding surfaces of a viral RNA-dependent RNA polymerase.
Claims24
A pharmacophore of a binding surface of a viral RNA-dependent RNA polymerase, wherein the pharmacophore is characterized by a) selective binding to a binding surface on a viral RNA-dependent RNA polymerase and b) inhibition of viral RNA-dependent RNA polymerase activity.
A composition for treating a viral infection, comprising:
- a pharmacophore characterized by a) selective binding to a binding surface of a viral RNA-dependent RNA polymerase and b) activity in disruption of viral RNA-dependent RNA polymerase activity;
- and
- a pharmaceutically acceptable carrier.
A computer comprising a representation of a pharmacophore in computer memory that either designs a molecular structure that possesses a biological activity or screens a molecular structure for possession of the biological activity wherein the pharmacophore comprises:
- a three-dimensional array of points defining a specific shape and volume, wherein the three-dimensional array of points is an aggregate average shape of a molecule or a plurality of molecules that optimally fit a binding interface of a viral RNA-dependent RNA polymerase, wherein the aggregate average shape is represented by a coordinate system configured in computer memory, and the molecule or the plurality of molecules possess the same or similar biological activity.
Dependencies are inferred from the claim text.