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OwnerJoseph M. Patti, Paul Domanski +1inventors
InventorsJoseph M. Patti, Paul Domanski, Pratiksha Patel
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Monoclonal and polyclonal antibodies to the binding subdomains of the MAP protein, including the Map10 protein, or other immunogenic subregions of the MAP protein, are provided which can be useful in the treatment of and protection against infection from staphylococcal bacteria such as Staphylococcus aureus. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the antibodies of the present invention are advantageous because they serve the double purpose of preventing adherence of the bacteria to host cells and enhancing the killing of the bacteria in an infected host.
An isolated antibody which binds to the Map10 protein from S. aureus.
A method of inducing an immunological response comprising administering to a human or animal an isolated S. aureus Map10 protein.
A method of identifying antibodies to the Map10 protein comprising adding an isolated Map10 protein to a sample suspected of containing anti-MAP antibodies, and determining if antibodies have bound to the added Map10 protein.
An isolated antibody which binds to the Map10 protein from S. aureus.
An isolated antibody having a variable light sequence according to SEQ ID NO:4.
An isolated antibody having a variable heavy sequence according to SEQ ID NO:6.
An isolated S. aureus Map10 protein.
Dependencies are inferred from the claim text.