Combination anti-selectin and immunosuppressant therapy
OwnerPaul C. Harrison, Jeffrey B. Madwed +2inventors
InventorsPaul C. Harrison, Jeffrey B. Madwed, Robert Rothlein, Takashi K. Kishimoto
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Abstract
A combination therapy of administering to a patient at least one selectin inhibitor and at least one immunosuppressant is employed in methods for modulating the patient's immune response, and in treatment regimens for organ and tissue transplant rejections and various inflammatory disorders. In some embodiments, the selectin inhibitor is an antibody to L-selectin or P-selectin such as a Dreg series of monoclonal antibody, or a functional fragment thereof, or SLex or a SLex derivative or mimetic, and the immunosuppressant is cyclosporin A.
Claims20
A method for modulating the immune response in a patient comprising administering to the patient an effective amount of a combination of at least one selectin inhibitor and at least one immunosuppressant.
An improvement in immunosupressant therapy comprising administering to a patient in need thereof an effective amount of at least one immunosuppressant in combination with at least one selectin inhibitor.
A pharmaceutical composition comprising at least one immunosuppressant and at least one selectin inhibitor.
Use of a selectin inhibitor with an immunosupressant to modulate the immune response of a patient.
Dependencies are inferred from the claim text.