Back to results
US 2002/0164333 A1Published application
Bifunctional molecules and vectors complexed therewith for targeted gene delivery
AssigneeThe Scripps Research Institute
InventorsGlen R. Nemerow, Erguang Li
Life of this patent
Estimating the term…
Abstract
Methods and products for targeting delivery vectors, such as adenoviral gene delivery particles, to selected cell types are provided. The methods rely on targeting by a bifunctional molecule that specifically complexes with a protein on the vector particle surface and with targeted cell surface proteins. The targeted cell surface proteins are any that activate the phosphatidylinositol-3-OH kinases. The bifunctional molecules, compositions, kits, and methods of preparation and use of the vector/bifunctional molecules for gene therapy are provided.
Claims39
A bifunctional molecule, comprising:
- an antibody or antigen-binding portion thereof and a targeting agent, wherein:
- the antibody specifically binds to an antigen in a protein that binds to αv integrin;
- and
- the targeting agent specifically binds to a cell surface protein that activates the phosphatidylinositol 3 (PI3K) signaling pathway.
1 more element
Dependencies are inferred from the claim text.