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US 2002/0164332 A1Published application
Mammalian cytokines; related reagents and methods
AssigneeSchering Corporation
InventorsJoseph A. Hedrick, Theodore R. Sana, J. Fernando Bazan, Robert A. Kastelein
Life of this patent
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Abstract
Nucleic acids encoding mammalian, e.g., rodent, IL-1δ, IL-1ε, purified IL-1δ and IL-1ε proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
Claims21
An isolated or recombinant polypeptide:
- A) that:
- a) specifically binds polyclonal antibodies generated against a 12 consecutive amino acid segment of SEQ ID NO:
- 2;
- and
- b) comprises at least one sequence selected from the following group (see SEQ ID NO:
- 2):
- 6 LeuCysPheArgMetLysAsp;
- ValLeuTyrLeuHisAsn;
- GlnLeuLeuAlaGly;
- IleSerValValProAsn;
- SerProValIleLeuGlyVal;
- GlnCysLeuSerCysGlyThr;
- ProIleLeuLysLeuGlu;
- PheTyrArgArgAspMetGly;
- LeuThrSerSerPheGluSer;
- PheLeuCysThrSer;
- GlnProValArgLeuThr;
- PheTyrPheGlnGln;
- ArgAlaLeuAspAlaSerLeu;
- and GlyLeuHisAlaGluLysVal;
- B) that:
- a) specifically binds polyclonal antibodies generated against a 12 consecutive amino acid segment of SEQ ID NO:
- 6;
- and
- b) comprises at least one sequence selected from the following group (see SEQ ID NO:
- 6):
- 7 SerLeuArgHisValGlnAsp;
- ValTrpIleLeuGlnAsn;
- IleLeuThrAlaVal;
- IleThrLeuLeuProCys;
- AspProThrTyrMetGlyVal;
- SerCysLeuPheCysThrLys;
- ProValLeuGlnLeuGly;
- PheTyrHisLysLysSerGly;
- ThrThrSerThrPheGluSer;
- PheIleAlaValCys;
- CysProLeuIleLeuThr;
- PheGluMetIleVal;
- GlnAspLeuSer;
- ValProArgLysGluGlnThrVal;
- SerLysGlySerCysPro;
- ArgAlaAlaSer;
- ProCysGlnTyrLeuAspThrLeuGlu;
- and SerGlyThrThr;
- or
- C) that:
- a) specifically binds polyclonal antibodies generated against a 12 consecutive amino acid segment of SEQ ID NO:
- 13 or 15;
- and
- b) comprises at least one sequence selected from the following group (see SEQ ID NO:
- 13 or 15):
- 8 ITGTIND;
- VWTLQG;
- NLVAV;
- VAVITC;
- DPIYLGI;
- MCLYCEK;
- PTLQLK;
- FYPAKTG;
- RTSTLES;
- FIASS;
- QPIILT;
- FELNI;
- SMCK;
- NDLN;
- VPR(R/S)TSVT;
- VPRSDSVT;
- TCKYPEALE;
- TGRT;
- SKRDQP;
- or SKGDQP.
68 more elements
A binding compound comprising an antigen binding site from an antibody, which specifically binds to a mature polypeptide from:
- a) SEQ ID NO:
- 2;
- b) SEQ ID NO:
- 6;
- c) SEQ ID NO:
- 13;
- or
- d) SEQ ID NO:
- 15.
6 more elements
An isolated or recombinant nucleic acid that
- a) hybridizes under wash conditions of 40° C. and less than 1M salt to SEQ ID NO:
- 1;
- b) hybridizes under wash conditions of 40° C. and less than 1 M salt to SEQ ID NO:
- 3, 5, 12 or 14.
1 more element
Dependencies are inferred from the claim text.