Adsorption and removal of endotoxin from physiological fluids using cationic helix peptides
AssigneeCommonwealth Biotechnologies, Inc.
InventorsRobert B. Harris, Russell L. Wolz, Gabriella Wolz
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Abstract
The present invention provides endotoxin-binding peptides which are useful in the treatment and prevention of sepsis. The present invention further provides a method for treating or preventing sepsis comprising administration of the compounds of the present invention.
Claims6
A method for treating sepsis comprising administering to a patient in need of such treatment a molecule selected from the group consisting of Arg Helix #2, Bis Arg Helix #2, Tris-Arg Helix #3, Tetra-Arg Helix #3, and Tris-Arg Helix #3 Constrained.
A method for detecting endotoxin in a sample comprising
- providing a molecule selected from the group consisting of Arg Helix #2, Bis Arg Helix #2, Tris-Arg Helix #3, and Tris-Arg Helix #3 Constrained, wherein the molecule is labeled with a detectable label;
- contacting the sample with the labeled molecule, under conditions that permit the binding of the molecule to any endotoxin in the sample;
- and
- detecting the presence of any labeled molecule bound to endotoxin.
A method for removing endotoxin in a sample comprising
- providing a molecule selected from the group consisting of Arg Helix #2, Bis Arg Helix #2, Tris-Arg Helix #3, Tetra-Arg Helix #3, and Tris-Arg Helix #3 Constrained, wherein the molecule is bound to a solid support;
- exposing the sample to the molecule bound to a solid support, under conditions that permit the binding of the molecule to any endotoxin in the sample;
- and
- collecting the sample.
Dependencies are inferred from the claim text.