Medical use of matrix metalloproteinase inhibitors for inhibiting tissue contraction
AssigneesUniversity of Florida Research Foundation, Inc., Moorfields Eye Hospital National Health Service Trust, The Institute of Ophthalmology
InventorsPeng Tee Khaw, Gregory S. Schultz
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Abstract
The use of an MMP inhibitor, especially a collagenase inhibitor, in the manufacture of a medicament for the treatment of a natural or artificial tissue comprising extracellular matrix components to inhibit contraction of the tissue and methods for the treatment of tissue comprising extracellular matrix components to inhibit contraction.
Claims25
The use of a matrix metalloproteinase inhibitor in the manufacture of a medicament for the treatment or prophylaxis of a natural or artificial tissue comprising extracellular matrix components to inhibit contraction of the tissue.
The use of a collagenase inhibitor in the manufacture of a medicament for the treatment or prophylaxis of tissue comprising collagen to inhibit contraction of the tissue resulting from contraction of the collagen.
The use of a matrix metalloproteinase inhibitor to inhibit the invasion by cells, especially fibroblasts, into tissue comprising an extracellular matrix and/or the migration by cells, especially fibroblasts, in or through tissue comprising an extracellular matrix by cells.
A pharmaceutical preparation, other than a preparation suitable for use in the eye, suitable for application to a wound, burn or skin graft comprising a matrix metalloproteinase inhibitor.
A method for the inhibition, for cosmetic reasons, of contraction of tissue comprising extracellular matrix components, which method comprises administering a matrix metalloproteinase inhibitor to the tissue.
A method for the inhibition of contraction in vivo of a natural or artificial tissue comprising extracellular matrix components, which comprises administering a therapeutically effective amount of a matrix metalloproteinase inhibitor to the tissue.
A method for the inhibition of contraction in vitro of a natural or artificial tissue comprising extracellular matrix components, which comprises administering a matrix metalloproteinase inhibitor to the tissue.
A method for the inhibition of contraction of tissue comprising collagen resulting from contraction of the collagen, which comprises administering a therapeutically effective amount of a collagenase inhibitor to the tissue.
The invention as claimed in any one of claims to 11 in which the inhibitor is a monoclonal or a polyclonal antibody.
A method of treating a human or other mammal to inhibit contraction of tissue comprising an extracellular matrix component, especially contraction associated with a chemical burn, a thermal burn or a radiation burn, a skin graft, a post-trauma condition resulting from surgery or an accident, glaucoma surgery, diabetes associated eye disease, scleroderma, Dupytren's contracture, epidermolysis bullosa or a hand or foot tendon injury, which comprises administering to the human or other mammal a therapeutically effective amount of a matrix metalloproteinase inhibitor.
Dependencies are inferred from the claim text.