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US 2002/0164315 A1Published application
Polyampholytes for delivering polyions to a cell
AssigneeMirus Bio Corporation
InventorsJon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy
Life of this patent
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Abstract
An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
Claims16
A process for enhancing delivery of a polygon to a cell, comprising:
- a) forming a complex of polyampholyte containing a cleavable bond and polygon;
- and,
- b) delivering the complex into a cell.
A complex for delivering a polygon to a cell, comprising:
- a) a polygon;
- and,
- b) a cleavable polyampholyte wherein the polygon and the cleavable polyampholyte are bound in complex.
A process for extravasation of a complex, comprising:
- a) forming a complex of polyampholyte and polygon;
- and,
- b) inserting the complex into a blood vessel;
- c) delivering the complex to an extravascular space.
1 more element
Dependencies are inferred from the claim text.