Adenoviral-vector-mediated gene transfer into medullary motor neurons
AssigneesAventis Pharma S.A., Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsFRANCOISE FINIELS, MINERVA GIMENEZ-RIBOTTA, JACQUES MALLET, ALAIN PRIVAT, FREDERIC REVAH
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and compositions for delivering nucleic acids to motor neurons by administering the nucleic acids to muscle tissue. The invention relates to methods for treating pathologies of the nervous system, such as trauma and neurodegenerative diseases.
Claims64
A method of muscle reinnervation and of inducing peripheral or collateral sprouting of motor axon endings comprising administering one or more nucleic acids to muscle tissue
A method of producing a protein in mammalian motor neurons comprising administering one or more nucleic acids encoding said protein to muscle tissue, wherein said nucleic acids are delivered to said motor neurons and expressed.
A method of treating an impairement of the nervous system, comprising administering to muscle tissue of a mammal suffering therefrom nucleic acids encoding neurotrophin-3 and a nucleic acid encoding CNTF.
Use of one or more nucleic acids for the preparation of a composition useful for muscle reinnervation and for inducing the sprouting of motor axons endings.
Use of one or more nucleic acids for the preparation of a composition useful for producing a protein in mammalian motor neurons comprising administering said one or more nucleic acids encoding said protein to muscle tissue, wherein said nucleic acids are delivered to said motor neurons and expressed.
Use of one or more nucleic acids for the preparation of a composition useful for treating an impairement of the nervous system comprising administering to muscle tissue of a mammal suffering therefrom nucleic acids encoding neurotrophin-3 and a nucleic acid encoding CNTF.
Dependencies are inferred from the claim text.