TNF and IFN stimulated genes and uses therefor

A method for identifying an agent which modulates an TNF & IFN influenced cellular process or response, the method comprising:

• a) exposing a sample of cells to TNF & IFN;
• b) determining the activity in the sample of cells of the product of one or more TNF & IFN stimulated genes (Table 1 and 2) in the presence and absence of a selected agent;
• and
• c) identifying that the agent modulates an TNF & IFN influenced cellular process or response when the activity of the product of the one or more TNF & IFN stimulated genes in the cell sample in the presence of the agent differs from the activity of the product of the one or more TNF & IFN stimulated genes in the absence of the agent.

A method for identifying an agent which modulates an TNF & IFN influenced cellular process or response, the method comprising:

• a) providing a sample of cells;
• b) determining the level of expression in the sample of cells of one or more TNF & IFN stimulated genes (Tables 1 and 2) in the presence and absence of a selected agent;
• and
• c) identifying that the agent modulates an TNF & IFN influenced cellular process or response when the expression of the one or more TNF & IFN stimulated genes in the cell sample in the presence of the agent differs from the expression of the one or more TNF & IFN stimulated genes in the absence of the agent.

A method for identifying an agent which modulates an TNF & IFN influenced cellular process or response, the method comprising:

• a) providing a sample of cells;
• b) determining the activity in the sample of cells of the product of one or more TNF & IFN stimulated genes (Table 1 and 2) in the presence and absence of a selected agent;
• and
• c) identifying that the agent modulates an TNF & IFN influenced cellular process or response when the activity of the product of the one or more TNF & IFN stimulated genes in the cell sample in the presence of the agent differs from the activity of the product of the one or more TNF & IFN stimulated genes in the absence of the agent.

A method for detecting or monitoring a cellular process or response that is influenced by TNF & IFN, the method comprising:

• a) obtaining a sample of cells from a patient;
• b) determining the level of expression in the sample of cells of one or more TNF & IFN stimulated genes (Tables 1 and 2);
• and
• c) identifying that the cells in the sample of cells obtained from the patient are undergoing a cellular process or response that is influenced by TNF & IFN when the level of expression of the one or more TNF & IFN stimulated genes in the cell sample is increased relative to the level of expression of the one or more TNF & IFN stimulated genes in a control the sample.

A method for detecting or monitoring a cellular process or response that is influenced by TNF & IFN, the method comprising:

• a) obtaining a sample of cells from a patient;
• b) determining the level of activity in the sample of cells of the product of one or more TNF & IFN stimulated genes (Tables 1 and 2);
• and
• c) identifying that the cells in the sample of cells obtained from the patient are undergoing a cellular process or response that is influenced by TNF & IFN when the level of activity of the product of the one or more TNF & IFN stimulated genes in the cell sample is increased relative to the activity of the product of the one or more TNF & IFN stimulated genes in a control the sample.

A method for assessing whether cells will be responsive to an agent which modulates an TNF & IFN influenced cellular process or response comprising the steps of

• a) exposing a sample of cells obtained from a patient to a test agent;
• b) determining the level of expression in the sample of cells of the one or more TNF & IFN stimulated genes (Tables 1 and 2) in the sample exposed to the agent and in a sample of cells that is not exposed to the agent;
• and
• c) determining that the cells will be responsive to the agent when expression of the one or more of the TNF & IFN stimulated genes is altered in the presence of the agent.

A method for assessing whether cells will be responsive to an agent which modulates an TNF & IFN influenced cellular process or response comprising the steps of

• a) exposing a sample of cells obtained from a patient to a test agent;
• b) determining the level of activity of the product of the one or more TNF & IFN stimulated genes (Tables 1 and 2) in the sample of cells exposed to the agent and in a sample of cells that is not exposed to the agent;
• and
• c) determining that the cells will be responsive to the agent when activity of the product of the one or more TNF & IFN stimulated genes in the cell sample in the presence of the agent differs from the activity of the product of the one or more INF & IFN stimulated genes in the absence of the agent.