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AssigneeWilliam Marsh Rice University
InventorsLon J. Wilson, John T. Wharton, Uri Sagman
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An contrast agent for therapeutic or diagnostic treatment comprises a fullerene scaffold and an iodinated moiety bonded to the scaffold. The agent may further comprise a water solubilizing moiety bonded to the scaffold, which may be a serinol malonodiamide, hydroxyl, and 1,3-diol. The fullerene scaffold may comprise an empty fullerene or an endohedral fullerene. A method for making the agent includes a) synthesizing iodinating moieties, b) protecting serinols, forming protected serinols, c) attaching the protected serinols to the iodinated moieties, forming iodinated serinols, d) attaching the iodinated serinols to the fullerene scaffold, and, optionally, d) de-protecting the serinols. Also disclosed are a method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety, a method of making a blood pool agent.
An agent for therapeutic or diagnostic treatment comprising:
A method for iodinating a fullerene scaffold comprising:
21 The method of claim 19 wherein at least four iodinated serinols are attached to the fullerene scaffold.
A method of water solubilizing a fullerene scaffold comprising attaching a plurality of serinol malonodiamide groups to the fullerene scaffold.
A method for iodinating and water solubilizing a fullerene scaffold comprising:
A method for providing diagnostic treatment to a patient comprising administering to said patient a radiopaque effective amount of a contrast agent comprising a fullerene scaffold and an iodinated moiety.
A method of making a blood pool agent, comprising:
A tissue-specific agent comprising:
Dependencies are inferred from the claim text.