Purification process
AssigneeBiogal Gyogyszergyar Rt.
InventorsVilmos Keri, Arvai Edit Nagyne, Lajos Deak, Gyorgyne Mako, Istvanne Miskolczy
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Abstract
Object of the invention is a process for the chromatographic purification of cyclosporin A from a crude product containing cyclosporin complex by using a column filled with silica gel and by the application of multistep chromatography with a column filled with normal phase silica gel and by a solvent mixture containing toluene as the major component.
Claims27
A purification process for the preparation of cyclosporin A in high purity from crude product containing cyclosporin complex comprising multistep silica gel column chromatography in which the mobile phase is a solvent comprising toluene as the main component.
An industrial scale process for the purification of cyclosporin A from cyclosporin complex containing crude product comprising multistep silica gel column chromatography using normal phase silica gel as a stationary phase and a solvent comprising toluene as the main component of the mobile phase.
Dependencies are inferred from the claim text.