US 2002/0162127 A1 · Human protein kinase domain-containing protein

Abstract

The invention provides isolated nucleic acids that encode a human protein kinase domain-containing portein (STTK), and fragments thereof, vectors for propagating and expressing STTK nucleic acids, host cells comprising the nucleic acids and vectors of the present invention, proteins, protein fragments, and protein fusions of the novel STTK isoforms, and antibodies thereto. The invention further provides transgenic cells and non-human organisms comprising STTK nucleic acids, and transgenic cells and non-human organisms with targeted disruption of the endogenous orthologue of the STTK gene. The invention further provides pharmaceutical formulations of the nucleic acids, proteins, and antibodies of the present invention, and diagnostic, investigational, and therapeutic methods based on the STTK nucleic acids, proteins, and antibodies of the present invention.

Claims47

Dependent claims

An isolated nucleic acid that encodes a Serine/Threonine/Tyrosine protein kinase, comprising:

(a) a nucleotide sequence selected from the group consisting of:
(i) SEQ ID NO:
1;
(ii) the complement of the sequences set forth in (i);
(iii) the nucleotide sequence of SEQ ID NO:
2;
(iv) a degenerate variant of the sequences set forth in (iii);
and
(v) the complement of the sequences set forth in (iii) and (iv);
or
(b) a nucleotide sequence selected from the group consisting of:
(i) a nucleotide sequence that encodes a polypeptide having the sequence of SEQ ID NO:
3;
(ii) a nucleotide sequence that encodes a polypeptide having the sequence of SEQ ID NO:
3, with conservative amino acid substitutions;
and
(iii) the complement of the sequences set forth in (i) and (ii),
wherein said isolated nucleic acid comprising a nucleotide sequence selected from group (b) is no more than about 100 kb in length.

15 more elements

Dependencies are inferred from the claim text.

Human protein kinase domain-containing protein

Life of this patent

Human protein kinase domain-containing protein

Life of this patent

Abstract

Claims47