Composite bone marrow graft material with method and kit
AssigneeThe Cleveland Clinic Foundation
InventorGeorge F. Muschler
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Abstract
A composite bone marrow graft material is provided having an enriched population of uniformly distributed progenitor cells. The graft material includes clot material preferably derived from non-anticoagulated bone marrow aspirate, which significantly improves the efficacy of the graft. A method for preparing such bone graft material is also provided. A kit is also provided containing sterilized implements useful in preparing enriched composite bone marrow graft material.
Claims33
A composite bone marrow graft material comprising a porous biocompatible implantable matrix and clot material, said composite bone marrow graft material having an enriched population of progenitor cells.
A method of preparing composite bone marrow graft material comprising the steps of:
- a) providing a bone marrow aspirate;
- b) providing a porous biocompatible implantable matrix;
- c) contacting said bone marrow aspirate and said matrix to provide an enriched matrix;
- and
- d) mechanically mixing said enriched matrix to yield a composite bone marrow graft material having progenitor cells distributed substantially uniformly throughout said composite bone marrow graft material.
A kit for the preparation of composite bone marrow graft material, said kit comprising a matrix container, a first endcap, and a first loading syringe, said first endcap being releasably attachable to said matrix container, said first endcap and said first loading syringe being adapted to connect to each other to provide fluid communication between said first loading syringe and said matrix container.
Dependencies are inferred from the claim text.