Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
AssigneeNeoMend, Inc.
InventorsGregory M. Cruise, Olexander Hnojewyj
Life of this patent
Estimating the term…
Abstract
A biocompatible and biodegradable barrier material is applied to a tissue region, e.g., to seal a vascular puncture site. The barrier material comprises a compound, which is chemically cross-linked without use of an enzyme to form a non-liquid mechanical matrix. The compound preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(ethylene) glycol (PEG), and, most preferably, a multi-armed PEG polymer.
Claims12
A method for creating a biocompatible and biodegradable barrier to seal a vascular puncture site comprising the steps of
- providing a first liquid component,
- providing a second liquid component, the first and second liquid components being free of an enzyme, and
- mixing the first and second liquid components by dispensing the components into a catheter tube deployed at the vascular puncture site, wherein, upon mixing, the first and second liquid components chemically cross-link to form a mechanical non-liquid matrix sealing the vascular puncture site.
A method for creating a biocompatible barrier comprising the steps of mixing a protein solution and a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid matrix.
A method for creating a biocompatible barrier comprising the steps of
- providing a protein solution,
- providing a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, and
- mixing the protein and polymer solutions by dispensing the protein solution and the polymer solution into a channel, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid matrix.
A method for creating a biocompatible barrier to seal a vascular puncture site comprising the steps of
- providing a protein solution,
- providing a polymer solution including a derivative of a hydrophilic polymer with a functionality of at least three, and
- mixing the protein and polymer solutions by dispensing the protein solution and the polymer solution into a catheter tube deployed at a vascular puncture site, wherein, upon mixing, the protein solution and the polymer solution cross-link to form a mechanical non-liquid matrix sealing the puncture site.
Dependencies are inferred from the claim text.