Organic reactions with CO generating materials
AssigneeBiotage AB
InventorsMats Larhed, Mathias Alterman, Yiqian Wan, Anders Hallberg, Nils-Fredrik Kaiser
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Abstract
The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to an energy source to release carbon monoxide from the CO releasing compound and wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound. The present invention is further drawn to a method of preparing chemical libraries and a kit for organic reactions.
Claims36
A method of performing a one-pot organic reaction,which includes carbon monoxide as reactant and does not use of an external CO gas source, which comprises
- preparing a reaction mixture containing a non-catalysing solid or liquid CO releasing compound, a non-metal substrate compound and a metal catalyst;
- and
- exposing said reaction mixture to an energy source to release carbon monoxide from the CO releasing compound,
- wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound.
The method according to any of the preceding claims wherein the reaction mixture further comprises an additional reactant.
A method of preparing a chemical library which comprises
- preparing a reaction mixture containing a non-catalysing solid or liquid CO releasing compound, a non-metal substrate compound and a metal catalyst;
- and
- exposing the reaction mixture to an energy source to release carbon monoxide from the CO releasing compound,
- wherein the carbon atoms of the released carbon monoxide form a bond with a non-metal substrate compound.
A kit for organic reactions including CO as reactant comprising a one or more solid or liquid CO releasing compounds, selected from metal carbonyls of the general formula I,
- Mx(CO)y
- wherein M is a metal, x is an integer, y is an integer, or formamides of the general formula II,
- HCONR1R2
- wherein R1 and R2 independently can be H, or an optionally substituted, linear or branched alkyl, aryl or alkylaryl group.
Dependencies are inferred from the claim text.