Quinazolines for treating brain tumor
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Rama Krishna Narla, Xing-Ping Liu
Life of this patent
Estimating the term…
Abstract
Novel substituted quinozaline compounds and conjugates useful to inhibit the growth of brain tumor cells and to inhibit adhesion and migration of brain tumor cells. The compounds of the invention include 4-(3′-bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline and this compound covalently bound to EGF.
Claims47
A compound comprising the formula:
- 38
- wherein X is selected from the group consisting of HN, R11N, S, O, CH2, and R11CH;
- R11 is H, alkyl having up to four carbon atoms, or acyl;
- R1, R2, R3, R4 and R5 are the same or different and are each independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, alkoxy, acyl, and alkylthio, having up to four carbon atoms, and where one or more of R1-R5 is OH, SH, or NH2;
- R6, R7 and R8 are the same or different and are each independently selected from the group consisting of H, OH, SH, NH2, NO2, alcyl, alkoxy, alkylthio and halogens, having up to four carbon atoms;
- and
- R9 and R10 are the same or different and are each independently selected from the group consisting of H, alkyl or acyl, having up to four carbon atoms.
A compound comprising the formula:
- 39
- wherein R11 is H or alkyl having up to four carbon atoms;
- R1, R2, R3, R4 and R5 are the same or different and are each independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, alkoxy, acyl, and alkylthio, having up to four carbon atoms, and where one or more of R1-R5 is OH, SH, or NH2;
- R6, R7 and R8 are the same or different and are each independently selected from the group consisting of H, OH, SH, NH2, NO2, halogen, alcyl, alkoxy, and alkylthio, having up to four carbon atoms;
- and
- R9 and R10 are the same or different and are each independently selected from the group consisting of H, alkyl or acyl, having up to four carbon atoms.
A compound having the structural formula:
- 43
A compound having the structural formula:
- 44
A compound having the structural formula:
- 45
A compound having the structural formula:
- 46
A compound having the structural formula:
- 47
A compound having the structural formula:
- 48
A compound having the structural formula:
- 49
A conjugate compound comprising 4-(3′-Bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxy quinazoline [WHI-P154) covalently bonded to EGF.
A conjugate compound comprising 4-(3′-Bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxy quinazoline [WHI-P131) covalently bonded to EGF.
A conjugate compound comprising 4-(3′-Bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxy quinazoline [WHI-P292) covalently bonded to EGF.
A method of treating brain tumor comprising administering to a brain tumor patient a conjugate compound comprising 4-(3′-bromo-4′-hydroxy phenyl)-amino-6,7-dimethoxyquinazoline covalently bound to EGF.
Dependencies are inferred from the claim text.