Trail receptors nucleic acids encoding the same and methods of use thereof
AssigneeThomas Jefferson University
InventorEmad S. Alnemri
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Abstract
In accordance with the present invention, there are provided isolated mammalian TRAIL receptor proteins, antibodies thereto, therapeutic compositions, and nucleic acids encoding such. Bioassays and therapeutic methods employing invention DR5 and TRAIL-R3 proteins are also provided.
Claims30
An isolated nucleic acid encoding a mammalian TRAIL receptor selected from the group consisting of DR5 and TRAIL-R3, splice variant cDNA sequences thereof, or an active fragment thereof.
A nucleic acid encoding a mammalian TRAIL receptor, wherein said nucleic acid is selected from the group consisting of:
- (a) DNA encoding the amino acid sequence set forth in SEQ ID NO:2, SEQ ID NO:4, or SEQ ID NO:6;
- (b) DNA that hybridizes to the DNA of (a) under moderately stringent conditions, wherein said DNA encodes biologically active DR5 or TRAIL-R3;
- (c) DNA degenerate with respect to either (a) or (b) above, wherein said DNA encodes biologically active DR5,or TRAIL-R3;
- and
- (d) splice variant cDNA sequences of any of (a)-(d).
An isolated mammalian protein selected from the group consisting of DR5, a DR5 splice variant, TRAIL-R3, and a TRAIL-R3 splice variant, wherein said protein is characterized by being able to bind TRAIL ligand.
Dependencies are inferred from the claim text.