Helicobacter pylori live vaccine
OwnerThomas F. Meyer, Rainer Haas +6inventors
InventorsThomas F. Meyer, Rainer Haas, Yan Zhengxin, Oscar Gomez-Duarte, Bernadette Lucas, Jochen Maurer, Carol Patrice Gibbs, Claus Tobias Lattemann
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Abstract
The present invention relates to novel recombinant live vaccines, which provide protective immunity against an infection by Helicobacter pylori and a method of screening H. pylori antigens for optimized vaccines.
Claims16
a recombinant attenuated microbial pathogen, which comprises at a least one heterologous nucleic acid molecule encoding a Helicobacter antigen, wherein said pathogen is capable to express said nucleic acid molecule or capable to cause the expression of said nucleic acid molecule in a target cell.
A method for identifying Helicobacter antigens, which raise a protective immune response in a mammalian host, comprising the steps of:
- a) providing an expression gene bank of Helicobacter in an attenuated pathogen and
- b) screening the clones of the gene bank for their ability to confer protective immunity against a Helicobacter infection in a mammalian host.
Dependencies are inferred from the claim text.