Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Servic
InventorsLawrence H. Lazarus, Severo Salvadori
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Abstract
A compound of formula: 1 wherein X is a spacer comprising one or more amino acid residues and Y comprises an aromatic group and related compositions and methods of use.
Claims10
A compound of formula:
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- wherein X is a spacer comprising at least one amino acid residue, and Y comprises an aromatic group.
A compound of formula:
- 30
- wherein R′ is selected from the group consisting of
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A method of treating a mammal in need of an antagonist of a δ-opioid receptor, which method comprises administering at least one compound of formula:
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- wherein R′ is selected from the group consisting of:
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- in an amount that antagonizes a δ-opioid receptor in said mammal.
A method of treating a mammal in need of an agonist of a δ-opioid receptor, which method comprises administering at least one compound of formula:
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- wherein R′ is
- in an amount that agonizes a δ-opioid receptor in said mammal.
A method of treating a mammal in need of an agonist of a μ-opioid receptor, which method comprises administering at least one compound of formula:
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- wherein R′ is
- in an amount that agonizes a μ-opioid receptor in said mammal.
A compound of formula:
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- wherein R′ is
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Dependencies are inferred from the claim text.