Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom
OwnerShalaby W. Shalaby, Dan Akerfeldt +3inventors
InventorsShalaby W. Shalaby, Dan Akerfeldt, Fredrik Preiniz, Per Egnelov, Torbjorn Mathisen
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Abstract
An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
Claims17
An absorbable, crystalline, monocentric, polyaxial copolymer comprising:
- a central atom selected from the group consisting of carbon and nitrogen;
- and
- at least three axes originating and extending outwardly from the central atom, each axis comprising:
- an amorphous, flexible component adjacent to and originating from the central atom, the amorphous component comprising repeat units derived from at least one cyclic monomer selected from the group consisting essentially of carbonates and lactones;
- and
- a rigid, crystallizable component extending outwardly from the amorphous, flexible component, the crystallizable component comprising repeat units derived from at least one lactone;
- wherein the copolymer comprises a melting temperature greater than 120° C., a heat of fusion greater than 10 J/g, and an endothermic transition at 40-100° C., wherein the endothermic transition can be controlled by subsequent heat treatment of the copolymer.
A device for sealing a puncture in a blood vessel, comprising:
- a first flexible sealing member, positionable inside the blood vessel immediately adjacent to the puncture;
- an elongated member comprising a composite and having an axial direction, a cross-sectional diameter, a proximal end and a distal end, wherein the first sealing member is attached to the distal end of the elongated member, the elongated member being capable of positioning the first sealing member within the blood vessel and immediately adjacent to the puncture, the elongated member further comprising a distal locking portion comprising an enlarged cross-sectional diameter at the distal portion which extends outwardly from the punctured blood vessel when the first sealing member is positioned within the blood vessel and immediately adjacent to the puncture;
- and
- a second flexible sealing member threadable onto the elongated member by an opening defined therein, the second sealing member comprising locking means for locking onto the distal locking portion of the elongated member, such that the second sealing means is locked onto the elongated member on the outside of the blood vessel immediately adjacent to the puncture thereby sealing the puncture.
Dependencies are inferred from the claim text.