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US 2002/0161045 A1Published application
Novel acetyloxymethyl esters and methods for using the same
AssigneeBeacon Laboratories, Inc.
InventorsHsuan-Yin Lan-Hargest, Norbert L. Wiech
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Abstract
Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds are effective in the inhibition of histone deacetylase.
Claims16
A compound having the formula (1):
- 4
- wherein R is substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, a cis or trans retinoyl group, or has the general formula (2):
- Z—(X)o—(R1)p—(R2)q— (2)
- wherein Z is selected from the group consisting of hydrogen and substituted or unsubstituted aryl, heteroaryl, cycloalkyl having the formula CnH2n-l, and alkoxy;
- wherein n is 3 or greater;
- wherein X is S, O, C═O or CH2;
- wherein R1 is S, O, CH═CH or C≡C;
- wherein R2 is CH2, CH═CH or C≡C;
- and
- wherein o, p and q are the same or different are each between 0 and 10, but when o is zero and R1 or R2 is CH═CH or C≡C, Z is not hydrogen or alkoxy.
7 more elements
A method for treating an illness in a patient comprising administering to said patient an effective amount of a compound having the formula (1):
- 5
- wherein R is substituted or unsubstituted C2-C10 alkenyl, substituted or unsubstituted C2-C10 alkynyl, a cis or trans retinoyl group, or has the general formula (2):
- Z—(X)O—(R1)p—(R2)q— (2)
- wherein Z is selected from the group consisting of hydrogen and substituted or unsubstituted aryl, heteroaryl, cycloalkyl having the formula CnH2n-l, and alkoxy;
- wherein n is 3 or greater;
- wherein X is S, O, C═O or CH2;
- wherein R1 is S, O, CH═CH or C≡C;
- wherein R2 is CH2, CH═CH or C≡C;
- and
- wherein o, p and q are the same or different are each between 0 and 10, but when o is zero and R1 or R2 is CH═CH or C≡C, Z is not hydrogen or alkoxy.
7 more elements
Dependencies are inferred from the claim text.