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US 2002/0161037 A1Published application
Continuous process for preparing dihydropyrones
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsOliver Meyer, Markus Sauter, Mark Goehlich
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Abstract
The invention relates to a continuous process for preparing dihydropyrones of general formula I, 1 wherein the groups R1 and R2 have the meanings described herein.
Claims11
A process for preparing a compound of general formula (I),
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- wherein
- R1 is a C1-C8-alkyl, C6-C10-aryl-C1-C4-alkyl or C3-C8-cycloalkyl-C1-C4-alkyl group, and
- R2 is a C1-C8-alkyl group, comprising:
- reacting a) a ketone of formula (II)
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- wherein R1 and R2 are as hereinbefore defined,
- with an acetoacetate in the presence of a strong base and
- b) cyclising the resulting compound of formula (IV)
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- wherein
- R3 denotes a C1-C4-alkyl or benzyl group, by means of a base, wherein a compound of formula II is continuously mixed and reacted with an acetoacetate in the form of its dianion in a microreactor, and subsequently isolating the product compound of the general formula (I).
9 more elements
Dependencies are inferred from the claim text.