US 2002/0161036 A1 · Chalcone coumarins

Abstract

The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor and immune suppressive agents, as inhibitors of proliferative cell growth and as prophylactic agents to inhibit and prevent cancer and non-malignant cell growth.

Claims30

Dependent claims

A compound of Formula (I):

4
or a pharmaceutically acceptable salt or solvate thereof wherein:
Ar represents:
a substituted or unsubstituted, (preferably aromatic), carbocyclic or heterocyclic group, said carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents on the Ar group being independently selected from the group consisting of.
(a) Cl, (b) Br, (c) F, (d) OH, (e) NO2, (f) CF3, (g) C1-4 lower alkyl (in particular CH3), (h) SCH3, (i) NHCOCH3, (j) N(R6)(R8) wherein R6 and R8 are the same or different and each represents H or lower C1-4 alkyl, (k) OR10 wherein R10 represents a saturated or unsaturated lower C1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1, 2 or 3 substituents selected from:
Cl, Br, F, OMe, NO2 and CF3,
and (I) —OCOR11, wherein R11 represents a saturated or unsaturated lower
C1-6 straight or branched hydrocarbyl group or a phenyl group;
R represents
OH, OR10 or OCOR11, wherein R10 and R11 are as defined above;
and
R1 represents H or a lower C1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1, 2 or 3 substituents selected from Cl, Br, F, OMe, NO2 and CF3.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/075,625Filed 15 Feb 2002

Priority

GB 9920908.23 Sep 1999

Published

31 Oct 2002

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 405/06
Containing two hetero rings: linked by a carbon chain containing only aliphatic carbon atoms
A61K 31/37
Having six-membered rings, e.g. delta-lactones: coumarins, e.g. psoralen
A61P 15/12
Drugs for genital or sexual disorders ; Contraceptives: for climacteric disorders
A61P 19/10
For bone diseases, e.g. rachitism, Paget's disease: for osteoporosis

Abstract

Claims30

Dependent claims

A compound of Formula (I):

4
or a pharmaceutically acceptable salt or solvate thereof wherein:
Ar represents:
a substituted or unsubstituted, (preferably aromatic), carbocyclic or heterocyclic group, said carbocyclic or heterocyclic group containing from 5 to 10 ring atoms, said ring atoms forming one or two rings, wherein the or each ring contains 5 or 6 ring atoms, any heteroatoms being selected from N, O and S, any substituents on the Ar group being independently selected from the group consisting of.
(a) Cl, (b) Br, (c) F, (d) OH, (e) NO2, (f) CF3, (g) C1-4 lower alkyl (in particular CH3), (h) SCH3, (i) NHCOCH3, (j) N(R6)(R8) wherein R6 and R8 are the same or different and each represents H or lower C1-4 alkyl, (k) OR10 wherein R10 represents a saturated or unsaturated lower C1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1, 2 or 3 substituents selected from:
Cl, Br, F, OMe, NO2 and CF3,
and (I) —OCOR11, wherein R11 represents a saturated or unsaturated lower
C1-6 straight or branched hydrocarbyl group or a phenyl group;
R represents
OH, OR10 or OCOR11, wherein R10 and R11 are as defined above;
and
R1 represents H or a lower C1-6 straight or branched hydrocarbyl group which may be unsubstituted or substituted by 1, 2 or 3 substituents selected from Cl, Br, F, OMe, NO2 and CF3.

9 more elements

Dependencies are inferred from the claim text.

Chalcone coumarins

Life of this patent

Abstract

Claims30

Chalcone coumarins

Life of this patent

Abstract

Claims30