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US 2002/0161035 A1Published application
Medicaments for chemotherapeutic treatment of disease
AssigneePhotogen, Inc.
InventorsH. Craig Dees, Timothy C. Scott
Life of this patent
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AssigneePhotogen, Inc.
InventorsH. Craig Dees, Timothy C. Scott
Estimating the term…
New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.
A medicament comprising at least one halogenated xanthene as a primary active component, wherein said medicament is useful for chemotherapeutic treatment of human and animal tissue.
The medicament of claim I wherein said halogenated xanthene is in a delivery vehicle that includes an adjuvant selected from the group consisting of builders, stabilizers, emulsifiers, dispersants, preservatives, buffers, electrolytes, tissue penetrating agents and tissue softening agents.
The medicament of claim I wherein said medicament is usefuil for the treatment of indications selected from the group consisting of conditions affecting the skin and related organs, conditions affecting the mouth and digestive tract and related organs, conditions affecting the urinary and reproductive tracts and related organs, conditions affecting the respiratory tract and related organs, conditions affecting the circulatory system and related organs, conditions affecting the head and neck, conditions affecting the endocrine and lymphoreticular systems and related organs, conditions affecting connective tissues, conditions affecting tissue surfaces exposed during surgery, and conditions related to microbial, viral, fungal, and parasitic infection.
Use of a halogenated xanthene in the preparation of a medicament for chemotherapeutic treatment of human and animal tissue.
Use of a halogenated xanthene comprising:
The use of claim l wherein said halogenated xanthene comprises Rose Bengal.
A pharmaceutical composition for intracorporeal administration comprising a halogenated xanthene for chemotherapeutic treatment.
A method of treating comprising:
A medicament comprising at least one halogenated xanthene as a primary active component, wherein such medicament is useful for chemotherapeutic treatment, of human and animal tissue.
A pharmaceutical composition adapted for chemotherapeutic effect, comprising a dosage unit of a halogenated xanthene.
Dependencies are inferred from the claim text.