Stablization of quinapril using magnesium oxide
AssigneeWarner-Lambert Company
InventorsJane Ellen Daniel, Michael Ray Harris, Gerard Clifford Hokanson, Jay Weiss
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Abstract
The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms of degradation when prepared in a pharmaceutical composition consisting essentially of magnesium oxide as the stabilizing agent. The presence of magnesium oxide also lends itself to favorable processing conditions during the manufacture of ACE inhibitor-containing compositions, especially processing by wet granulation.
Claims2
A pharmaceutical composition which contains:
- (a) quinapril;
- (b) a suitable amount of a stablizer to retard cyclization and discoloration of quinapril, the stablizer consisting essentially of magnesium oxide;
- and
- (c) a suitable amount of a hydrolysis-minimizing agent to inhibit hydrolysis.
A pharmaceutical composition which contains:
- (a) quinapril;
- (b) a suitable amount of a stablizer to retard cyclization and discoloration, the stablizer consisting essentially of magnesium oxide;
- and
- (c) a suitable amount of a saccharide to inhibit hydrolysis.
Dependencies are inferred from the claim text.