Enhancement of the potency and efficacy of local anesthetics with ibutilide and other methanesulfonamide drugs
OwnerForrest L. Smith, Raymond Lindsayinventors
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Abstract
The efficacy of amide- and ester-linked local anesthetics is increased by administering methanesulfonamide compounds (for example, ibutilide and sotalol) as adjuvants with the local anesthetics. The effectiveness of these compounds as adjuvants is further increased by the concomitant administration of epinephrine. Pharmaceutical compositions comprising an amide- and ester-linked local anesthetic and a methanesulfonamide compound, which may further include epinepherine, are also provided.
Claims18
A method for increasing the potency of an amide-linked or ester-linked local anesthetic in a patient comprising the step of,
- administering at least one methanesulfonamide compound with an amide-linked or ester-linked local anesthetic or combination thereof.
A method of providing local anesthesia to a patient in need thereof, comprising the step of
- administering to said patient at least one amide-linked or ester-linked local anesthetic together with at least one methanesulfonamide compound.
A pharmaceutical composition comprising,
- at least one amide-linked or ester-linked local anesthetic, and
- at least one methanesulfonamide compound.
Dependencies are inferred from the claim text.