Potassium channel inhibitors

A compound having potassium channel inhibitory activity of formula (I), or a pharmaceutically acceptable salt or prodrug thereof:

• 40
• wherein,
• A, B, and D are selected from a substituted carbon atom, a nitrogen atom, or N→O, wherein at least one of A, B, and D is a substituted carbon atom and at most only one of A, B and D is N→O;
• E is hydrogen, or alkyl;
• G is hydrogen, or alkyl;
• or E and G taken together form a bond (site of unsaturation);
• R1 is selected from hydrogen, alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, and (heteroaryl)alkyl;
• R2 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, and (heteroaryl)alkyl;
• R3 is selected from hydrogen (H), alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heterocyclo, (heterocyclo)alkyl, heteroaryl, (heteroaryl)alkyl, aminoalkyl;
• substituted aminoalkyl, carboxyalkyl, alkoxyalkanoyl, aminoalkanoyl, substituted aminoalkanoyl, alkanoylamidoalkyl, alkanoyl(substituted amido)alkyl, aroylamidoalkyl, aroyl(substituted amido)alkyl, heterocyclocarbonylamidoalkyl, heterocyclocarbonyl(substituted amido)alkyl, heteroaroylamidoalkyl, and heteroaroyl(substituted amido)alkyl;
• R4 is selected from alkyl, carbocycloalkyl, aryl, (aryl)alkyl, heteroaryl and heterocyclo;
• R5 and R6 are each independently selected from hydrogen, fluoro and alkyl, or R5 and
• R6 taken together, along with the carbon atom to which they are both attached, form a 3-membered to 7-membered carbocyclic, or heterocyclic ring;
• R7 is independently selected from hydrogen, alkyl, hydroxy, alkoxy, amino, substituted amino, nitro, cyano, halo, carboxy, alkoxycarbonyl, aminocarbonyl, substituted aminocarbonyl and n is 1, 2 or 3;
• and
• Z is selected from hydrogen, alkyl, hydroxy, SH, alkoxy, aryloxy, alkylthio, amino, substituted amino, alkoxycarbonyl, alkanoylamido, aroylamido, heterocyclocarbonylamido, heteroaroylamido, alkanoyl(alkylsubstituted) amido, aroyl(alkylsubstituted)amido, heteroaroyl(alkylsubstituted)amido, and heterocyclocarbonyl(alkyl substituted)amido.