Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
OwnerJacques F. Banchereau, Anna Karolina Palucka +1inventors
InventorsJacques F. Banchereau, Anna Karolina Palucka, Patrick Blanco
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Abstract
The invention provides a method for treating an autoimmune disease in a subject by administerineng an interfron antagonist and Flt3 ligand (Flt3L) antagonist. The invention also provides compositions containing one or more interferon antagonists, and one or more Flt3L antagonists, an in vitro assay for determining a subject's risk for developing an autoimmune disease, and kits for use, inter alia, with the assay.
Claims52
A method for treating an autoimmune disease in a subject which comprises administering to the subject an effective amount of (a) at least one interferon antagonist that reduces activity of a type I interferon, and (b) at least one Flt3 ligand (Flt3L) antagonist that reduces activity of a Flt3L to thereby treat the autoimmune disease.
A therapeutic composition to inhibit monocyte differentiation into dendritic cells capable of antigen presentation which comprises:
- (a) at least one interferon antagonist that reduces activity of a type I interferon, and (b) at least one FIt3 ligand (Flt3L) antagonist that reduces activity of Flt3L.
An in vitro assay for determining a subject's risk for developing an autoimmune disease which comprises:
- (a) obtaining a serum sample from the subject;
- (b) quantifying IFN-α and Flt3 ligand (Flt3L) in the serum sample;
- and
- (c) comparing the quantity of IFN-α and Flt3L with the quantities of IFN-α and Flt3L in serum from subjects with an autoimmune disease, thereby determining the subject's risk for developing an autoimmune disease.
A kit for determining a subject's risk for developing an autoimmune disease or for monitoring the status of an autoimmune disease in a subject which comprises a composition which specifically binds to Flt3L and to IFN-α in an amount effective to detect Flt3L and IFN-α in a biological sample of a subject.
Dependencies are inferred from the claim text.