Retroviral vectors with foreign-sequence insertion between retroviral primer binding site and retroviral splice donor

Retroviral vector with the general structure

• 5′-[LTR]-[PBS]-[SD]-[Ψ]-[SA]-[PP]-[LTR]-3 ′,
• in which
• 3 [LTR] is the terminal sequence repeat (long terminal repeat, LTR) of the retroviral vector, [PBS] is the retroviral primer binding site, [SD] is the retroviral splice donor signal, [Ψ] is the retroviral packaging signal, [SA] is the retroviral splice acceptor signal, and [PP] is a polypurine tract (PP tract),
• characterized in that
• the vector contains, between the retroviral primer binding site (PBS) and the retroviral splice donor (SD), a further foreign sequence [FS1] which is selected from the group composed of enhancer-promoter sequences, enhancer sequences, cDNA sequences, sequences for chromatin-modification, and/or sequences for RNA processing signals.