Conjugates comprising galactose alpha 1,3 galactosyl epitopes and methods of using same
OwnerRichard M. Jack, David S. Jones +1inventors
InventorsRichard M. Jack, David S. Jones, Lin Yu
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Abstract
This invention provides conjugates useful for xenotransplantation which comprise a galactose α1,3 galactosyl (αGal) epitope conjugated to a valency platform molecule, preferably a chemically defined valency platform molecule which allows precise valency. The invention also provides compositions comprising these conjugates, and methods (such as methods for inducing tolerance) using these conjugates and compositions.
Claims30
A conjugate comprising a valency platform molecule and an αGal epitope, wherein the valency platform molecule has a valency from two to 128.
A conjugate comprising a valency platform molecule and an αGal epitope, wherein the valency platform molecule has a valency of at least two.
Dependencies are inferred from the claim text.