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US 2002/0160952 A1Published application
Inhibition of protein-protein interaction
OwnerAleksey G. Kazantsev, David E. Housman +2inventors
InventorsAleksey G. Kazantsev, David E. Housman, Leslie M. Thompson, J. Lawrence Marsh
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Abstract
The invention features inhibition of protein-protein interaction by therapeutic agents, which can be used to treat numerous disorders, including those associated with expanded CAG repeats.
Claims17
A therapeutic agent comprising
- (a) a first domain that binds a first protein, the first protein having at least seven consecutive glutamine residues;
- (b) a second domain that binds a second protein, the second protein having at least seven consecutive glutamine residues;
- and
- (c) a third domain that separates the first domain from the second domain.
1 more element
An isolated DNA molecule, wherein the DNA molecule encodes a polypeptide having three domains:
- (a) a first domain that binds a first protein, the first protein having at least seven consecutive glutamine residues;
- (b) a second domain that binds a second protein, the second protein having at least seven consecutive glutamine residues;
- and
- (c) a third domain that separates the first domain from the second domain.
1 more element
Dependencies are inferred from the claim text.