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US 2002/0160950 A1Published application
Cytochrome P450 variant
OwnerPreeti G. Lal, Yalda Azimzai +1inventors
InventorsPreeti G. Lal, Yalda Azimzai, Y. Tom Tang
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Abstract
The invention provides human cytochrome P450 variants (CYTPV) and polynucleotides which identify and encode CYTPV. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CYTPV.
Claims51
An isolated polypeptide selected from the group consisting of:
- a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1,
- b) a polypeptide comprising a naturally occurring amino acid sequence at least 98% identical to the amino acid sequence of SEQ ID NO:1,
- c) a biologically active fragment of a polypeptide having the amino acid sequence of SEQ ID NO:1, and
- d) an immunogenic fragment of a polypeptide having the amino acid sequence of SEQ ID NO:1.
1 more element
An isolated polynucleotide selected from the group consisting of:
- a) a polynucleotide comprising the polynucleotide sequence of SEQ ID NO:2,
- b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to the polynucleotide sequence of SEQ ID NO:2,
- c) a polynucleotide complementary to a polynucleotide of a),
- d) a polynucleotide complementary to a polynucleotide of b), and
- e) an RNA equivalent of a)-d).
2 more elements
Dependencies are inferred from the claim text.