Synergistic method for prolonging allograft survival
AssigneeMillennium Pharmaceuticals, Inc.
InventorsPeter J. Elliott, Wayne W. Hancock
Life of this patent
Estimating the term…
Abstract
The invention relates to allograft transplantation. More particularly, the invention relates to prolonging the survival of transplanted allografts. The invention provides a new method for improving allograft survival in a mammal. The method according to the invention provides a synergistic effect between lactacystin or lactacystin analogs and immunosuppressive drugs to prolong the survival of transplanted allografts in a mammal.
Claims13
A method for prolonging allograft survival in a mammal bearing an allograft, the method comprising administering a compound having the structure:
- 4
- wherein R1 is selected from the group consisting of C1-C6 alky, C3-C6 cycloalkyl, phenyl and phenyl(C1-C4)alkyl;
- and R2 is selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and iso-butyl;
- and further comprising administering to the mammal an immunosuppressive drug.
A method for prolonging allograft survival in a mammal bearing an allograft, the method comprising administering a compound having the structure:
- 5
- and further comprising administering to the mammal an immunosuppressive drug.
Dependencies are inferred from the claim text.