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US 2002/0160940 A1Published application
Modulation of endogenous gene expression in cells
AssigneeSangamo BioSciences, Inc.
InventorsCasey C. Case, Alan Wolffe, Fyodor Urnov, Albert Lai, Andrew Snowden, Siyuan Tan, Philip Gregory
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Abstract
Disclosed herein are methods and compositions for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
Claims34
A method of modulating expression of an endogenous cellular gene in a cell, the method comprising the step of:
- contacting a first target site in the endogenous cellular gene with a designed or selected zinc finger protein, wherein the protein comprises a functional domain;
- thereby modulating expression of the endogenous cellular gene.
Dependencies are inferred from the claim text.