Human vitreous and pharmaceutical compositions
OwnerRichard Mayne, Zhao-Xia Ren +1inventors
InventorsRichard Mayne, Zhao-Xia Ren, Jiangang Liu
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Abstract
In the vitreous, collagen fibrils and hyaluronan molecules form independent networks that interact to maintain the transparency of the vitreous gel. The discovery of the full length cDNA sequence of human vitrin makes it possible to produce the protein and its separate domains by known biotechnological means. It was found that vitrin is released from the collagen fibrils at high salt concentrations. The protein and expressed domains of the invention may be used to facilitate healing of weakened or injured connective tissue.
Claims7
A purified, isolated polypeptide or protein containing at least one von Willebrand sequence of human vitreous.
Dependencies are inferred from the claim text.