CAF1-related protein
AssigneeIncyte Genomics, Inc.
InventorsJennifer L. Hillman, Neil C. Corley, Henry Yue
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Abstract
The invention provides a human CAF1-related protein (CAFRP) and polynucleotides which identify and encode CAFRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CAFRP.
Claims55
An isolated polypeptide comprising an amino acid sequence selected from the group consisting of:
- a) a polypeptide comprising an amino acid sequence of SEQ ID NO:1,
- b) a naturally occurring polypeptide comprising an amino acid sequence at least 90% identical to an amino acid sequence of SEQ ID NO:1,
- c) a biologically active fragment of a polypeptide having an amino acid sequence of SEQ ID NO:1, and
- d) an immunogenic fragment of a polypeptide having an amino acid sequence of SEQ ID NO:1.
An isolated antibody which specifically binds to a polypeptide comprising an amino acid sequence selected from the group consisting of:
- c) a polypeptide comprising an amino acid sequence of SEQ ID NO:1,
- d) a naturally occurring polypeptide comprising an amino acid sequence at least 90% identical to an amino acid sequence of SEQ ID NO:1,
- e) a biologically active fragment of a polypeptide having an amino acid sequence of SEQ ID NO:1, and
- f) an immunogenic fragment of a polypeptide having an amino acid sequence of SEQ ID NO:1.
An isolated polynucleotide comprising a sequence selected from the group consisting of:
- a) a polynucleotide comprising a polynucleotide sequence of SEQ ID NO:2,
- b) a naturally occurring polynucleotide comprising a polynucleotide sequence at least 90% identical to a polynucleotide sequence of SEQ ID NO:2,
- c) a polynucleotide having a sequence complementary to a polynucleotide of a),
- d) a polynucleotide having a sequence complementary to a polynucleotide of b) and
- e) an RNA equivalent of a)-d).
Dependencies are inferred from the claim text.