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US 2002/0160474 A1Published application
Adipocyte complement related protein zacrp11
OwnerBrian A. Foxinventor
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Abstract
The present invention relates to polynucleotide and polypeptide molecules for zacrp11, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp11 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp11 protein or fragments thereof.
Claims21
A polypeptide selected from the group consisting of:
- (a) a polypeptide comprising amino acid residues 61-111 of SEQ ID NO:2;
- (b) a polypeptide comprising amino acid residues 21-111 of SEQ ID NO:2;
- (c) a polypeptide comprising amino acid residues 1-111 of SEQ ID NO:2;
- (d) a polypeptide comprising amino acid residues 112-219 of SEQ ID NO:2;
- (e) a polypeptide comprising amino acid residues 112-268 of SEQ ID NO:2;
- (f) a polypeptide comprising amino acid residues 61-219 of SEQ ID NO:2;
- (g) a polypeptide comprising amino acid residues 61-268 of SEQ ID NO:2;
- (h) a polypeptide comprising amino acid residues 21-219 of SEQ ID NO:2;
- (i) a polypeptide comprising amino acid residues 21-268 of SEQ ID NO:2;
- (j) a polypeptide comprising amino acid residues 1-219 of SEQ ID NO:2;
- and
- (k) a polypeptide comprising amino acid residues 1-268 of SEQ ID NO:2.
9 more elements
A fusion protein comprising a first portion and a second portion joined by a peptide bond, the first portion consisting of a polypeptide selected from the group consisting of:
- (a) a polypeptide comprising amino acid residues 61-111 of SEQ ID NO:2;
- (b) a polypeptide comprising amino acid residues 21-111 of SEQ ID NO:2;
- (c) a polypeptide comprising amino acid residues 1-111 of SEQ ID NO:2;
- (d) a polypeptide comprising amino acid residues 112-219 of SEQ ID NO:2;
- (e) a polypeptide comprising amino acid residues 112-268 of SEQ ID NO:2;
- (f) a polypeptide comprising amino acid residues 61-219 of SEQ ID NO:2;
- (g) a polypeptide comprising amino acid residues 61-268 of SEQ ID NO:2;
- (h) a polypeptide comprising amino acid residues 21-219 of SEQ ID NO:2;
- (i) a polypeptide comprising amino acid residues 21-268 of SEQ ID NO:2;
- (j) a polypeptide comprising amino acid residues 1-219 of SEQ ID NO:2;
- and
- (k) a polypeptide comprising amino acid residues 1-268 of SEQ ID NO:2;
- and
- the second portion comprising another polypeptide.
11 more elements
An isolated nucleic acid molecule encoding a polypeptide selected from the group consisting of:
- (a) a polypeptide comprising amino acid residues 61-111 of SEQ ID NO:2;
- (b) a polypeptide comprising amino acid residues 21-111 of SEQ ID NO:2;
- (c) a polypeptide comprising amino acid residues 1-111 of SEQ ID NO:2;
- (d) a polypeptide comprising amino acid residues 112-219 of SEQ ID NO:2;
- (e) a polypeptide comprising amino acid residues 112-268 of SEQ ID NO:2;
- (f) a polypeptide comprising amino acid residues 61-219 of SEQ ID NO:2;
- (g) a polypeptide comprising amino acid residues 61-268 of SEQ ID NO:2;
- (h) a polypeptide comprising amino acid residues 21-219 of SEQ ID NO:2;
- (i) a polypeptide comprising amino acid residues 21-268 of SEQ ID NO:2;
- (j) a polypeptide comprising amino acid residues 1-219 of SEQ ID NO:2;
- and
- (k) a polypeptide comprising amino acid residues 1-268 of SEQ ID NO:2.
9 more elements
A nucleic acid molecule encoding a fusion protein comprising a first portion and a second portion joined by a peptide bond, the first portion consisting of a polypeptide selected from the group consisting of:
- (a) a polypeptide comprising amino acid residues 61-111 of SEQ ID NO:2;
- (b) a polypeptide comprising amino acid residues 21-111 of SEQ ID NO:2;
- (c) a polypeptide comprising amino acid residues 1-111 of SEQ ID NO:2;
- (d) a polypeptide comprising amino acid residues 112-219 of SEQ ID NO:2;
- (e) a polypeptide comprising amino acid residues 112-268 of SEQ ID NO:2;
- (f) a polypeptide comprising amino acid residues 61-219 of SEQ ID NO:2;
- (g) a polypeptide comprising amino acid residues 61-268 of SEQ ID NO:2;
- (h) a polypeptide comprising amino acid residues 21-219 of SEQ ID NO:2;
- (i) a polypeptide comprising amino acid residues 21-268 of SEQ ID NO:2;
- (j) a polypeptide comprising amino acid residues 1-219 of SEQ ID NO:2;
- and
- (k) a polypeptide comprising amino acid residues 1-268 of SEQ ID NO:2;
- and
- the second portion comprising another polypeptide.
11 more elements
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule consisting of nucleotides 181-333 of SEQ ID NO:1;
- b) a nucleic acid molecule consisting of nucleotides 61-333 of SEQ ID NO:1;
- c) a nucleic acid molecule consisting of nucleotides 1-333 of SEQ ID NO:1;
- d) a nucleic acid molecule consisting of nucleotides 334-657 of SEQ ID NO:1;
- e) a nucleic acid molecule consisting of nucleotides 334-804 of SEQ ID NO:1;
- f) a nucleic acid molecule consisting of nucleotides 118-657 of SEQ ID NO:1;
- g) a nucleic acid molecule consisting of nucleotides 118-804 of SEQ ID NO:1;
- h) a nucleic acid molecule consisting of nucleotides 64-657 of SEQ ID NO:1;
- i) a nucleic acid molecule consisting of nucleotides 64-804 of SEQ ID NO:1;
- j) a nucleic acid molecule consisting of nucleotides 1-657 of SEQ ID NO:1;
- k) a nucleic acid molecule consisting of nucleotides 1-804 of SEQ ID NO:1;
- and
- l) a nucleic acid molecule consisting of SEQ ID NO:3.
10 more elements
An expression vector comprising the following operably linked elements:
- a transcription promoter;
- a DNA segment encoding a polypeptide with an amino acid sequence consisting of:
- (a) amino acid residues 61-111 of SEQ ID NO:2;
- (b) amino acid residues 21-111 of SEQ ID NO:2;
- (c) amino acid residues 1-111 of SEQ ID NO:2;
- (d) acid residues 112-219 of SEQ ID NO:2;
- (e) amino acid residues 112-268 of SEQ ID NO:2;
- (f) amino acid residues 61-219 of SEQ ID NO:2;
- (g) amino acid residues 61-268 of SEQ ID NO:2;
- (h) amino acid residues 21-219 of SEQ ID NO:2;
- (i) amino acid residues 21-268 of SEQ ID NO:2;
- (j) amino acid residues 1-219 of SEQ ID NO:2;
- and
- (k) amino acid residues 1-268 of SEQ ID NO:2;
- and
- a transcription terminator.
13 more elements
A method of producing an antibody to a polypeptide comprising:
- inoculating an animal with a polypeptide selected from the group consisting of:
- (a) a polypeptide consisting of 9 to 252 amino acids, wherein the polypeptide is a contiguous sequence of amino acids in SEQ ID NO:2 from amino acid residue 1 to amino acid residue 268;
- (b) a polypeptide consisting of amino acid residues 61-1 11 of SEQ ID NO:2;
- (c) a polypeptide consisting of amino acid residues 21-111 of SEQ ID NO:2;
- (d) a polypeptide consisting of amino acid residues 1-111 of SEQ ID NO:2;
- (e) a polypeptide consisting of amino acid residues 112-219 of SEQ ID NO:2;
- (f) a polypeptide consisting of amino acid residues 112-268 of SEQ ID NO:2;
- (g) a polypeptide consisting of amino acid residues 61-219 of SEQ ID) NO:2;
- (h) a polypeptide consisting of amino acid residues 61-268 of SEQ ID NO:2;
- (i) a polypeptide consisting of amino acid residues 21-219 of SEQ ID NO:2;
- (j) a polypeptide consisting of amino acid residues 21-268 of SEQ ID NO:2;
- (k) a polypeptide consisting of amino acid residues 1-219 of SEQ ID NO:2;
- and
- (1) a polypeptide consisting of amino acid residues 1-268 of SEQ ID NO:2;
- and
- wherein the polypeptide elicits an immune response in the animal to produce the antibody;
- and
- isolating the antibody from the animal.
15 more elements
Dependencies are inferred from the claim text.